بررسی میزان انعطاف‌پذیری بازوی زنجیره‌های پروتئین شوک حرارتی کوچک به عنوان نانوعملگر

نوع مقاله: مقاله علمی پژوهشی

نویسندگان

1 هیئت علمی دانشگاه صنعتی خواجه نصیر طوسی

2 دانشگاه ازاد اسلامی واحد پردیس*مهندسی مکانیک

3 دانشجوی کارشناسی ارشد مهندسی مکاترونیک، دانشگاه صنعتی خواجه نصیر طوسی

چکیده

در این مقاله رفتار پروتئین چپرون شوک حرارتی کوچک در برابر تغییر دما براساس شبیه‌سازی دینامیک مولکولی مورد بررسی قرار گرفته است. تغییرات ساختاری در دمای نرمال و متغیر، برای یک و دو زنجیره از پروتئین مورد بررسی قرار گرفته است. نتایج نشان می‌دهد میزان انعطاف پذیری بازو به حدی است که کاهش دما در شبیه‌سازی یک زنجیره سبب بسته شدن بازو و کاهش جابه‌جایی مرکز جرم می‌شود. در شبیه‌سازی دو زنجیره نیز کاهش دما سبب بسته شدن بازوی یکی از زنجیره‌ها و باز شدن بازوی زنجیره دیگر می‌شود. این رفتار متضاد در جابه‌جایی مرکز جرم پروتئین نیز مشاهده می‌گردد.

کلیدواژه‌ها

موضوعات


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